Standalone strips
Start reading from anywhere, and there's a great chance you won't miss anything. If there's a storyline, it spans just over a couple strips.
A Softer World
Usually just a bit weird. Sometimes, however, it's a fascinating kind of weird :-) For most strips, I ignore the graphical part. Sorry, Emily. [detailed info]
Author: Emily Horne, Joey Comeau
Updates: Finished
Website: www.asofterworld.com
The Unfeasible Adventures of Beaver and Steve
Monumental grandiosity. Stellar beyond description. Me and Steve, that's a lifelong love affair. Please, Mr. Turner, come back to your masterpiece and DRAW MORE!!! [detailed info]
Author: James Turner
Updates: On hiatus
Website: www.beaverandsteve.com
The Book of Biff
One-panel strip with the most outstanding feature being the protagonist's eyebrow. [detailed info]
Author: Chris Hallbeck
Updates: On hiatus
Website: www.thebookofbiff.com
Brewster Rockit: Space Guy!
Captain Brewster Rockit and his crew (and his alter ego Short Attention Span Avenger) are here to conquer the Galaxy! Or, rather, not to get lost hopelessly, no matter if inside or outside the space station R.U. Sirius. [detailed info]
Author: Tim Rickard
Updates: Daily (Monday to Sunday)
Website: www.gocomics.com/brewsterrockit
Buridanův geneticky modifikovaný osel
Nerdy. Most probably you won't make head nor tail of it, as it's in Czech. There are a few strips translated to English, so feel free to give it a try. [detailed info]
Author: Jojin&HedgeHog
Updates: Random
Website: www.bugemos.com
Calvin & Hobbes
An ingenious ode to imagination. The best comic strip EVER. [detailed info]
Author: Bill Watterson
Updates: Daily (Monday to Sunday)
Website: www.calvinandhobbes.com
Cyanide & Happiness
The third best stick figure webcomic in the world. Simple, silly and crude; usually just an average quality stuff in my opinion, but sometimes they score a hit - and when they do, it's a big one. [detailed info]
Author: Matt Melvin, Rob DenBleyker, Dave McElfatrick, Kris Wilson
Updates: Daily (Monday to Sunday)
Website: www.explosm.net/comics
Last Kiss
Comic paying tribute to comics. Sort of. [detailed info]
Author: John Lustig
Updates: Weekly
Website: www.lastkisscomics.com
Oglaf
Often dirty. You don't mind, do you? [detailed info]
Author: Trudy Cooper
Updates: Weekly (Sunday)
Website: www.oglaf.com
Penny Arcade
THE gaming webcomic. [detailed info]
Author: Jerry Holkins, Mike Krahulik
Updates: Weekly (Monday, Wednesday, Friday)
Website: www.penny-arcade.com/comic
Red Meat
Minimalist. Deviant. Nice! [detailed info]
Author: Max Cannon
Updates: Weekly (Wednesday)
Website: www.redmeat.com
Sinfest
East and West, Heaven and Hell, Slick and 'Nique. Splendid piece of art, brilliant writing, exquisite Sunday strips. [detailed info]
Author: Tatsuya Ishida
Updates: Daily (Monday to Sunday)
Website: www.sinfest.net
Saturday Morning Breakfast Cereal
Single-panel bowl of punch. Lines. [detailed info]
Author: Zach Weinersmith
Updates: Daily (Monday to Sunday)
Website: www.smbc-comics.com
Wizard of Id
Medieval kingdom where the King is a fink, the Wizard is afraid of his wife, the chief knight is a coward and the Jester is a habitual drunkard. [detailed info]
Author: Brant Parker, Johnny Hart
Updates: Daily (Monday to Sunday)
Website: www.gocomics.com/wizardofid
Wumo (previously Wulffmorgenthaler)
Ranging from intellectual to primitive humor, there's probably no topic left untouched by this strip. Bonus: A fucked-up crazy-ass weirdo beaver. [detailed info]
Author: Mikael Wulff, Anders Morgenthaler
Updates: Daily (Monday to Sunday)
Website: www.gocomics.com/wumo
xkcd
A webcomic of romance, sarcasm, math, and language. El Magnifico! [detailed info]
Author: Randall Munroe
Updates: Weekly (Monday, Wednesday, Friday)
Website: www.xkcd.com